Dehydroepiandrosterone comes into subsequent oxidative transformation with production of 16Alpha-hydroxydehydroepiandrosterone . This oxidation is catalyzed by Cytochrome P450, family 3, subfamily A, polypeptide 7 ( CYP3A7)  ,  ,  and Cytochrome P450, family 3, subfamily A, polypeptide 4 ( CYP3A4)  ,  ,  . Oxidative metabolite of this reaction as well as Dehydroepiandrosterone can be further sulfated by steroid sulfatase (microsomal), isozyme S ( STS )  ,  ,  ,  ,  . Dehydroepiandrosterone and Dehydroepiandrosterone sulfate can be transformed into other compounds with hormonal activity, Androstendiol and Androstendiol sulfate , respectively. These two reactions are catalyzed by Hydroxysteroid (17-beta) dehydrogenase 1 ( HSD17B1)  ,  ,  ,  , Hydroxysteroid (17-beta) dehydrogenase 2 ( HSD17B2)  ,  ,  ,  , and Hydroxysteroid (17-beta) dehydrogenase 7 ( HSD17B7 )  ,  ,  ,  .
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