Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's Disease . 
Healing from Plantar Fasciitis will take a commitment from you. You’ll need to commit to daily rest periods, icing, stretching and the daily wear of specialized orthotics. Some people find it hard to make the time or make the promise to themselves to do what they need to in order to recover. If you’re finding this a challenge, consider the fact that undertaking the work of treating your Plantar Fasciitis now at home could save you from having to take injections or undergo costly surgeries later. Your chances for recovery are extremely good, if you’re ready to make the commitment, and Heel That Pain is ready to help you, every step of the way .
Methotrexate is given weekly as an intramuscular injection of 15 to 25 mg. Side effects are rare and include leukopenia and hypersensitivity interstitial pneumonitis. Hepatic fibrosis is the most severe potential sequela of long-term therapy. Patients with concomitant alcohol abuse and/or morbid obesity are more likely to develop hepatic fibrosis and therefore should not be treated with methotrexate. It is prudent to obtain a baseline chest radiograph and to monitor complete blood count, liver function and renal function every two weeks until the patient is receiving oral therapy, and every one to three months thereafter. Before methotrexate therapy is initiated, the risks of treatment and the possible need for a liver biopsy should be discussed with the patient.