Corticosteroids adjuvant analgesics

Although research has identified a wide variation in practice regarding the use of corticosteroids, our review did not identify any evidence from randomized controlled trials for or against the role of corticosteroids in the management of ocular toxoplasmosis. Several questions remain unanswered by well-conducted randomized trials in this context, including whether the use of corticosteroids as an adjunctive agent is more effective than the use of anti-parasitic therapy alone; if so, when corticosteroids should be initiated in the treatment regimen (early versus late course of treatment), and what would be the best dose and duration of steroid use.

Nous avons effectué des recherches dans plusieurs bases de données électroniques pour trouver des essais évaluant l'utilisation de corticostéroïdes dans la prise en charge de l'infestation toxoplasmique de l'œil. Nous n'avons trouvé aucun essai contrôlé randomisé pour promouvoir l'utilisation de corticostéroïdes en complément des antiparasitaires pour le traitement de la toxoplasmose de l'œil. D'autres recherches sont nécessaires et devraient avoir pour objectif de réunir des preuves favorables à l'utilisation systématique de corticostéroïdes dans la prise en charge des patients atteints de toxoplasmose oculaire et de déterminer la dose, la durée d'utilisation et le moment du démarrage optimaux au cours du traitement antiparasitaire. Des critères de jugement pertinents pour les patients, tels que le délai d'amélioration des signes et symptômes de déficience visuelle, devront être évalués dans les futurs essais qui aborderont cette question.

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Using gene transfer of SV40 large T-antigen in neuronal precursor cells of rats, a brain tumor model was established. The PNETs were histologically indistinguishable from the human counterparts and have been used to identify new genes involved in human brain tumor carcinogenesis. [34] The model was used to confirm p53 as one of the genes involved in human medulloblastomas, but since only about 10% of the human tumors showed mutations in that gene, the model can be used to identify the other binding partners of SV40 Large T- antigen, other than p53 . [35] Recently ,it has been generated a SHH-type mouse model with high-frequency of medulloblastoma, a Patched 1 heterozygous mice knockout for the medulloblastoma suppressor Tis21 (Patched1+-/Tis21 KO). [36] The high medulloblastoma frequency appears to be caused by the down regulation of Cxcl3, being Cxcl3 induced by Tis21. [36] Consistently, the treatment with Cxcl3 completely prevents the growth of medulloblastoma lesions in a Shh-type mouse model of medulloblastoma. [37] Thus, CXCL3 is a target for medulloblastoma therapy.

Corticosteroids adjuvant analgesics

corticosteroids adjuvant analgesics

Using gene transfer of SV40 large T-antigen in neuronal precursor cells of rats, a brain tumor model was established. The PNETs were histologically indistinguishable from the human counterparts and have been used to identify new genes involved in human brain tumor carcinogenesis. [34] The model was used to confirm p53 as one of the genes involved in human medulloblastomas, but since only about 10% of the human tumors showed mutations in that gene, the model can be used to identify the other binding partners of SV40 Large T- antigen, other than p53 . [35] Recently ,it has been generated a SHH-type mouse model with high-frequency of medulloblastoma, a Patched 1 heterozygous mice knockout for the medulloblastoma suppressor Tis21 (Patched1+-/Tis21 KO). [36] The high medulloblastoma frequency appears to be caused by the down regulation of Cxcl3, being Cxcl3 induced by Tis21. [36] Consistently, the treatment with Cxcl3 completely prevents the growth of medulloblastoma lesions in a Shh-type mouse model of medulloblastoma. [37] Thus, CXCL3 is a target for medulloblastoma therapy.

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