Convulsions, increased intracranial pressure (including pseudotumor cerebri ), and toxic psychosis have been reported in patients receiving fluoroquinolones, including CIPRO IV. CIPRO IV may also cause central nervous system (CNS) events including: nervousness, agitation, insomnia, anxiety, nightmares, paranoia, dizziness, confusion, tremors, hallucinations, depression, and, psychotic reactions have progressed to suicidal ideations/thoughts and self-injurious behavior such as attempted or completed suicide. These reactions may occur following the first dose. Advise patients receiving CIPRO IV to inform their healthcare provider immediately if these reactions occur, discontinue the drug, and institute appropriate care. CIPRO IV, like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold. As with all fluoroquinolones, use CIPRO with caution in epileptic patients and patients with known or suspected CNS disorders that may predispose to seizures or lower the seizure threshold (for example, severe cerebral arteriosclerosis , previous history of convulsion , reduced cerebral blood flow, altered brain structure, or stroke ), or in the presence of other risk factors that may predispose to seizures or lower the seizure threshold (for example, certain drug therapy, renal dysfunction). Use CIPRO IV when the benefits of treatment exceed the risks, since these patients are endangered because of possible undesirable CNS side effects. Cases of status epilepticus have been reported. If seizures occur, discontinue CIPRO. [See ADVERSE REACTIONS and DRUG INTERACTIONS ]
I won’t lie and tell you that I haven’t thought about trying the protocol again. The fact is I have had fairly severe osteoporosis since my 30’s, including some bad breaks. Steroids are very hard on bones. I also have digestive problems, and take high doses of indomethacin – a drug known for causing serious digestive side effects. Adding steroids to the heap isn’t something any of my subsequent doctors and specialists have been comfortable with trying as it could be dangerous. We’ve tried injectables and smaller doses of prednisone, with far less spectacular results, but to date nothing near the experience I had with the IV.
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