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NSAIDs have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects. Although different NSAIDs have different structures, they all work by blocking cyclooxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation. Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

What results can I expect?
Revolution will kill the immature heartworms the pet was exposed to in the preceding month. For ear mites and sarcoptic mange, most mites are killed with one treatment, although a second treatment a month later may be required; follow the advice of your veterinarian. To control ticks, the dosage may need to be changed from the heartworm dose of once a month; again follow your veterinarian's recommendations. Most fleas are killed within 36 hours of application. If the pet was already infested with fleas when Revolution was applied, you may see fleas after that period of time as the immature forms of the fleas in the environment hatch.

Dog food itself can have a positive impact on dogs that are suffering from arthritis. In a clinical study, dogs that were fed a diet specifically formulated for dogs with OA (osteoarthritis) such as Hill's Prescription Diet j/d , a food rich in Omega-3 fatty acids , showed improvement over dogs that had a similar arthritic condition, but that were fed an ordinary diet. The results of the study showed that "more dogs in the test group had a reduction in pain at the end of the 90-day trial." 82% of the dogs in the trial that received the new diet showed improvement.

Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. In vitro , gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals. 1,2 Specifically, gentamicin is active against the following organisms isolated from canine skin: Alcaligenes sp., Citrobacter sp., Klebsiella sp., Pseudomonas aeruginosa , indole-positive and negative Proteus sp, Escherichia coli , Enterobacter sp., Staphylococcus sp., and Streptococcus sp.

Last but not least are the products that contain capsaicin , a hot pepper extract. Capsaicin is probably the most widely studied topical pain reliever known to mankind. And many types of products contain Capsaisin, including Icy Hot Arthritis Therapy, Capsin, and Rid-a-Pain (don’t you love that name). The theory behind the irritating hot pepper extract is that when applied, the painful burning sensation actually depletes the pain signal (Substance P) to the point that there is a refractory period of time in which no pain can be felt. 1 This theory is like yelling for a long period of time only to lose your voice. In essence, this topical treatment helps to desensitize the pain alarm. But first, you have to get past the initial burn and yelling. This topical is not for everyone, but it really can help conditions like painful diabetic neuropathy 2 and herpatic neuralgia. Capsaicin is still studied and utilized to this day, probably because it works for some.

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Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. In vitro , gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals. 1,2 Specifically, gentamicin is active against the following organisms isolated from canine skin: Alcaligenes sp., Citrobacter sp., Klebsiella sp., Pseudomonas aeruginosa , indole-positive and negative Proteus sp, Escherichia coli , Enterobacter sp., Staphylococcus sp., and Streptococcus sp.

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