A biopsy may be needed to determine the makeup of a suspicious looking area. There are different types of biopsies and your doctor can determine which one is best. Many doctors don’t use brush biopsies because while they're very easy, they still need a scalpel biopsy to confirm the results if the brush biopsy is positive. Also there are different types of scalpel biopsies, incisional and excisional, depending whether only a piece or the whole area is needed to determine what the nature of the problem is. Some doctors preform these biopsies with lasers.