Pharmacokinetic studies in men with Topicort® (desoximetasone) Ointment % with tagged desoximetasone showed no detectable level (limit of sensitivity: μg/mL) in 1 subject and and μg/mL in the remaining 2 subjects in the blood when it was applied topically on the back followed by occlusion for 24 hours. The extent of absorption for the ointment was 7% based on radioactivity recovered from urine and feces . Seven days after application, no further radioactivity was detected in urine or feces. Studies with other similarly structured steroids have shown that predominant metabolite reaction occurs through conjugation to form the glucuronide and sulfate ester.
Topical corticosteroids are available in a wide range of different strengths, from Class 1 (very strong) to Class 7 (very weak). Stronger corticosteroids are generally more effective in reducing moderate to severe symptoms, such as thick, chronic plaques, but are also more likely to cause side effects 2 . Lower strength corticosteroids are generally better for milder symptoms and for very sensitive areas of the body (such as the face or groin areas) and stronger strengths are better for areas with thicker skin (such as the knees and elbows).